2017年度 物質生命理工学科コロキウム
Robust cell type proportioning by a noisy oscillator
Prof. Chris R. Thompson (The University of Manchester, UK)
| 日時/場所 | 2017年5月17日（水） 11:00-12:00 2-508 |
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Robust cell type proportioning by a noisy oscillator
Prof. Chris R. Thompson (The University of Manchester, UK)
Cell fate decisions are tightly controlled to ensure robust and reproducible pattern during development. However, there is growing evidence that cell heterogeneity increase the spectrum of differentiation capabilities of cells in a uniform environment. This is seen in examples including the immune system, hES cells, and ‘salt and pepper’ lineage decisions in the mouse blastocyst and slime mould Dictyostelium. Despite this, our understanding of how heterogeneity can be harnessed to result in robust cell fate proportioning is still very poor. To address this, we study Dictyostelium patterning using single cell RNA-seq, live cell imaging, cell fate mapping, mathematical modeling and functional genomics. Our studies reveal a novel system in which a noisy cell fate oscillator can generate robust cell type proportioning because noise in oscillator dynamics is coupled directly to changes in signal responsiveness.
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